Kelly Orlando, Ph.D.

BIOGRAPHY:

Before joining the Immaculata faculty in 2012, Dr. Orlando was a postdoctoral fellow at the University of Pennsylvania, where she studied the establishment and maintenance of polarity in budding yeast, and then completed a teaching postdoc at Villanova University, where she studied the evolutionary conservation of genes across yeast species and taught laboratory and lecture courses such as cell and molecular biology and advanced cell biology. She has presented her research at meetings for various scientific associations, such as the American Society for Cell Biology and the Genetics Society of America.

Courses Taught:

• BIOL 234: Genetics
• BIOL 323: Microbiology
• BIOL209: Human Anatomy & Physiology I
• BIOL 210: Human Anatomy & Physiology II
• BIOL 291: Special Topics in Pharmacology

Publications:

• K. Orlando, C. Iosue, S. Leone, D. Davies and D. Wykoff. (2015) A paralogue of the phosphomutase-like gene family in Candida glabrata, CgPmu2, gained broad-range phosphatase activity due to a small number of clustered substitutions. Biochem. J. 471: 187-198.
• K. Orlando, X. Sun, J. Zhang, T. Lu, L. Yokomizo*, P. Wang and W. Guo. (2011) Exo-endocytic Trafficking and the Septin-based Diffusion Barrier Are Required for the Maintenance of Cdc42p Polarization during Asymmetrical Cell Growth in Budding Yeast. Mol. Biol. of the Cell. 22: 624-633. *(undergraduate mentee)
• K. Orlando and W. Guo. (2009) Membrane organization and dynamics in cell polarity. Cold Spring Harbor Perspect Biol. Nov; 1:a001321.
• K. Orlando, J. Zhang, X. Xhang, P. Yue, T. Chiang, E. Bi, and W. Guo. (2008) Regulation of Gic2 localization and function by PI(4,5)P2 during the establishment of cell polarity in budding yeast. J. Biol. Chem. 283: 14205-14212.
• K. Orlando and R. Pittman. (2006) Rho kinase regulates phagocytosis, surface expression of GlcNAc, and Golgi fragmentation of apoptotic cells. Exp. Cell Res. 312: 3298-3311.
• K. Orlando, N. Stone and R. Pittman. (2006) Rho kinase regulates fragmentation and phagocytosis of apoptotic cells. Exp. Cell Res. 312: 5-15.
• K. Orlando and R. Pittman. (2004) Current model and overview of the role of the cytoskeleton in apoptotic membrane blebbing. Recent Res. Dev. Cell Sci. 1: 49-59.

Research Interests:

My research interests include yeast cell biology and genetics, microbiology, and DNA barcoding of invertebrates.